Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness
Shuang Chao, Ziyan Shen, Yuxin Pei, Yinghua Lv, Xiaolin Chen, Jiaming Ren, Ke Yang, Zhichao Pei
Abstract
A galactose-targeting supramolecular photosensitizer system DOX@GP5⊃NBSPD was constructed based on a host-guest inclusion complex. The supramolecular system could achieve efficient delivery of DOX/NBS and selective release under GSH stimulation. In vitro studies revealed that this supramolecular DOX/NBS co-delivery system exhibited high ROS production and excellent cancer cell damage capability in a hypoxic environment. This strategy can therefore achieve enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination.
Topics & Concepts
PhotosensitizerSupramolecular chemistryPhotodynamic therapyPillarChemistryCancer researchCombinatorial chemistryNanotechnologyMaterials sciencePhotochemistryMedicineMoleculeOrganic chemistryStructural engineeringEngineeringNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsSupramolecular Chemistry and Complexes