Unlocking the synergistic potential of green metallic nanoparticles and antibiotics for antibacterial and wound healing activities
S.V.N. Pammi, Amir Mohammad Alipour, Ravichandra Matangi, Thirumala Rao Gurugubelli, Chandrasekar Perumalveeramalai, Lakshmi Kalyani Ruddaraju
Abstract
The discovery of antibiotics in the 20th century has played a crucial role in contemporary medicine for treating bacterial infections; however, the rise of antimicrobial resistance poses a significant threat to their efficacy, creating a global health crisis. On the other hand, the lack of discovery of new antibiotics for overcoming resistance has stagnated. In this context, metallic nanoparticles (MNPs) prepared with green approaches (P-MNPs) have emerged as viable options for combating multidrug-resistant bacteria and inhibiting biofilm formation. Additionally, when combined with commercial antibiotics, P-MNPs enhance drug delivery, improve circulation, and effectively target bacteria, reducing the required dosage and expanding antibacterial activity while maintaining biocompatibility. In this review, synergistic antibacterial mechanisms of P-MNPs and antibiotics (nAbts), their wound healing and cytotoxicity studies are underscored, which paves a road map for the researchers and medical practitioners to use nAbts in clinical translations.