Presymptomatic Awareness of Germline Pathogenic <i>BRCA</i> Variants and Associated Outcomes in Women With Breast Cancer
Tal Hadar, Pnina Mor, Gefen Amit, Sari Lieberman, David Gekhtman, Rachel Rabinovitch, Ephrat Levy‐Lahad
Abstract
morbidity resulting from SARS-CoV-2. Although the asymptomatic SARS-CoV carrier rate in children in the general population is not known, our testing of 120 asymptomatic pediatric patients with cancer revealed only a 2.5% rate of SARS-CoV-2 positivity. By comparison, we observed a 14.7% rate of SARS-CoV-2 positivity in their asymptomatic caregivers (2.5%; 95% CI, 0.5%-7.1% vs 14.7%; 95% CI, 7.3%-25.4%; P = .002), which closely matches the asymptomatic carrier rate in pregnant women in New York (13.5%). Together, our results do not support the conjecture that children are a reservoir of unrecognized SARS-CoV-2 infection.
Topics & Concepts
MedicineGermlineBreast cancerOncologyRetrospective cohort studyGermline mutationCancerInternal medicineBRCA mutationCohort studyGynecologyGeneticsMutationGeneBiologyBRCA gene mutations in cancerDNA Repair MechanismsCancer Genomics and Diagnostics