Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants
Fabian Offensperger, Franziska Müller, Jasmin Jansen, Daniel Hammler, Kathrin Götz, Andreas Marx, Carissa L. Sirois, Stormy J. Chamberlain, Florian Stengel, Martin Scheffner
Topics & Concepts
UBE3AUbiquitin ligaseAngelman syndromeDNA ligaseUbiquitinChemistryBiochemistryBiologyFunction (biology)GeneticsGeneCell biologyGenetic Syndromes and ImprintingCancer-related gene regulationEpigenetics and DNA Methylation