Dual stimuli-responsive polymeric nanoparticles combining soluplus and chitosan for enhanced breast cancer targeting
Shrouq Twal, Nisrein Jaber, Mayyas Al‐Remawi, Islam Hamad, Faisal Al‐Akayleh, Walhan Alshaer
Abstract
cellular uptake was evaluated by flow cytometry and confocal microscopy. The nanoparticles revealed a triggered increase in size upon reaching the lower critical solution temperature of SP, with 70% of drug release at acidic pH and 40 °C within the first hour and a 3.5-fold increase in cytotoxicity against MCF7 cells incubated at 40 °C. The cellular uptake study manifested that the prepared nanoparticles succeeded in delivering drug molecules to MCF7 and MDA-MB-231 cells. In summary, the distinctive characteristics provided by these novel CS-SP NPs result in a promising nano-platform for effective drug delivery in cancer treatment.
Topics & Concepts
NanocarriersChitosanBiocompatible materialDual (grammatical number)NanoparticleChemistryBreast cancerCopolymerNanotechnologyMaterials scienceBiomedical engineeringCancerMedicineBiochemistryPolymerOrganic chemistryInternal medicineLiteratureArtNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers