Coronary volume to left ventricular mass ratio in patients with diabetes mellitus
Jurriën H. Kuneman, Mohammed El Mahdiui, Alexander R. van Rosendael, Inge J. van den Hoogen, Manesh R. Patel, Bjarne Linde Nørgaard, Timothy Fairbairn, Koen Nieman, Takashi Akasaka, Daniel S. Berman, Lynne Koweek, Gianluca Pontone, Tomohiro Kawasaki, Niels Peter Rønnow Sand, Jesper Møller Jensen, Tetsuya Amano, Michael Poon, Kristian Altern Øvrehus, Jeroen Sonck, Mark Rabbat, Bernard De Bruyne, Campbell Rogers, Hitoshi Matsuo, Jeroen J. Bax, Jonathon Leipsic, Juhani Knuuti
Abstract
BACKGROUND: Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes. METHODS: Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes. RESULTS: /g, respectively, p = 0.006). CONCLUSION: The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation.