Reinvestigation of Passerini and Ugi scaffolds as multistep apoptotic inducers <i>via</i> dual modulation of caspase 3/7 and P53-MDM2 signaling for halting breast cancer
Mohammed Salah Ayoup, Yasmin Wahby, Hamida Abdel‐Hamid, Marwa M. Abu‐Serie, Sherif Ramadan, Assem Barakat, Mohamed Teleb, Magda M. F. Ismail
Abstract
prediction of the entire library was computationally performed, showing that most of them could be envisioned as drug-like candidates.
Topics & Concepts
ApoptosisInducerChemistryCancer researchDrug discoveryBreast cancerCancerComputational biologyBiologyBiochemistryMedicineGeneInternal medicineCell death mechanisms and regulationBioactive Compounds and Antitumor AgentsCancer-related Molecular Pathways