FGFR3 Alterations in the Era of Immunotherapy for Urothelial Bladder Cancer
Alec Kacew, Randy F. Sweis
Abstract
FGFR3 is a prognostic and predictive marker and is a validated therapeutic target in urothelial bladder cancer. Its utility as a marker and target in the context of immunotherapy is incompletely understood. We review the role of FGFR3 in bladder cancer and discuss preclinical and clinical clues of its effectiveness as a patient selection factor and therapeutic target in the era of immunotherapy.
Topics & Concepts
ImmunotherapyBladder cancerMedicineUrothelial cancerContext (archaeology)CancerCancer immunotherapyUrothelial CellCancer researchOncologyInternal medicineBiologyPaleontologyBladder and Urothelial Cancer TreatmentsFibroblast Growth Factor ResearchUrinary and Genital Oncology Studies