PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons
Joshua M. Marcus, Mohammed Iqbal Hossain, Jean‐Philippe Gagné, Guy G. Poirier, Lori L. McMahon, Rita M. Cowell, Shaida A. Andrabi
Topics & Concepts
Poly ADP ribose polymeraseCytosolOxidative stressNeuroprotectionPARP inhibitorCell biologyChromosomal translocationDNA damageBiologyProgrammed cell deathBiochemistryChemistryPolymeraseApoptosisDNAPharmacologyEnzymeGenePARP inhibition in cancer therapyIon channel regulation and functionParkinson's Disease Mechanisms and Treatments