Enriched circulating and tumor-resident TGF-β <sup>+</sup> regulatory B cells in patients with melanoma promote FOXP3 <sup>+</sup> Tregs
R. J. C. Harris, Zena Willsmore, Roman Laddach, Silvia Crescioli, Jitesh Chauhan, Anthony Cheung, Anna Black, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Sophia Tsoka, James Spicer, Katie E. Lacy, Sophia N. Karagiannis
Abstract
, an effect further enhanced with anti-PD-1 checkpoint blockade. Our findings reveal cytokine-expressing B cell compartments skewed toward regulatory phenotypes in patient circulation and melanoma lesions, intratumor spatial localization, and bidirectional crosstalk between B and T cell subsets with immunosuppressive attributes.
Topics & Concepts
FOXP3Regulatory B cellsCytokineCancer researchImmunologyIL-2 receptorTumor microenvironmentRegulatory T cellImmune systemT cellMelanomaBiologyMedicineInterleukin 10Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers