TMSCF2Br as both a C1 synthon and a F1 reagent
Danhua Ge, Zhenhua Jia, Xue‐Qiang Chu
Abstract
This highlight summarizes a recent development of KF-promoted three-component fluorination-aminocarbonylation reaction of aldehydes, tertiary amines, and TMSCF2Br for the synthesis of structurally important α-fluoroamide derivatives. The key to the success of this method could be attributed to the multiple functions of difluorocarbene precursor (TMSCF2Br) as both a C1 synthon and a F1 reagent through the process of C–F bond cleavage and C–F bond re-formation.
Topics & Concepts
SynthonDifluorocarbeneReagentChemistryCleavage (geology)Bond cleavageCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalysisMaterials scienceFracture (geology)Composite materialFluorine in Organic ChemistryInorganic Fluorides and Related Compounds