The immunogenicity of an anti-EGFR single domain antibody (VHH) is enhanced by misfolded amorphous aggregation but not by heat-induced aggregation
Md. Golam Kibria, Yoko Ogawa, Nafsoon Rahman, Yoshihisa Hagihara, Yutaka Kuroda
Topics & Concepts
ChemistryImmunogenicityProtein aggregationSingle-domain antibodyProtein foldingAntibodyBiophysicsMolecular biologyBiochemistryBiologyImmunologyProtein purification and stabilityMonoclonal and Polyclonal Antibodies ResearchToxin Mechanisms and Immunotoxins