Photoredox-mediated N-centered radical addition/semipinacol rearrangement for the convenient synthesis of β-amino (spiro)cyclic ketones
Tian-Cong Ma, Sheng Yao, Ming‐Ming Qiao, Fan Yuan, De‐Qing Shi, Wen‐Jing Xiao
Abstract
A photoredox-mediated N-centered radical addition/semipinacol rearrangement cascade of cycloalkanol-substituted 1<italic>H</italic>-indenes or styrenes with N-arylsulfonyl protected 1-aminopyridinium salts for the efficient synthesis of β-amino (spiro)cyclic ketones is presented.
Topics & Concepts
ChemistryCascadeCombinatorial chemistryStereochemistryChromatographyRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods