Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Shruti Koulgi, Vinod Jani, Mallikarjunachari Uppuladinne V N, Uddhavesh Sonavane, Rajendra Joshi
Abstract
Conformational changes in the remdesivir-bound RdRP leading to its inhibition.
Topics & Concepts
RNAMechanism (biology)RNA polymeraseCoronavirusSevere acute respiratory syndrome coronavirusRNA-dependent RNA polymeraseVirologyPolymeraseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Ligand (biochemistry)Coronavirus disease 2019 (COVID-19)ChemistryMedicineReceptorPhysicsGeneBiochemistryInternal medicineQuantum mechanicsInfectious disease (medical specialty)DiseaseSARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiologyAnimal Virus Infections Studies