Development of coumarin-thiosemicarbazone hybrids as aldose reductase inhibitors: Biological assays, molecular docking, simulation studies and ADME evaluation
Aqeel Imran, Muhammad Tariq Shehzad, Taha al Adhami, Khondaker Miraz Rahman, Dilawar Hussain, Rima D. Alharthy, Zahid Shafiq, Jamshed Iqbal
Topics & Concepts
Aldose reductaseChemistryAldose reductase inhibitorPolyol pathwayAldehyde ReductaseSorbitolCoumarinDocking (animal)SorbinilBiochemistryPharmacologyADMEIC50StereochemistryEnzymeIn vitroOrganic chemistryNursingMedicineAldose Reductase and TaurineEicosanoids and Hypertension PharmacologyFree Radicals and Antioxidants