Polylactic-Co-Glycolic Acid-Based Nanoparticles Modified with Peptides and Other Linkers Cross The Blood–Brain Barrier for Targeted Drug Delivery
Yue Na, Ning Zhang, Xinyu Zhong, Jinlian Gu, Chang Yan, Shun Yin, Xia Lei, Jihui Zhao, Fang Geng
Abstract
Because of the blood-brain barrier, only a limited fraction of drugs can penetrate the brain. As a result, there is a need to take larger doses of the drug, which may result in numerous undesirable side effects. Over the past few decades, a plethora of research has been conducted to address this issue. In recent years, the field of nanomedicine research has reported promising findings. Currently, numerous types of polylactic-co-glycolic acid-based drug-delivery systems are being studied, and great progress has been made in the modification of their surfaces with a variety of ligands. In this review, the authors highlight the preparation of polylactic-co-glycolic acid-based nanoparticles and single- and dual-targeted peptide modifications for site-specific drug delivery into the brain.