Derivation of Benzothiadiazine‐1,1‐dioxide Scaffolds via Transition Metal‐Catalyzed C—H Activation/Annulation
Ruizhi Lai, Shuran Xu, Qingyao Zhang, Hui Zhou, Cankun Luo, Yuerong Wang, Hai Li, Yong Wu
Abstract
Comprehensive Summary Benzothiadiazine‐1,1‐dioxide scaffold is bioactive framework with wild utility and applications. Synthesis of benzothiadiazine‐fused isoquinoline derivatives and spiro benzothiadiazine derivatives through transition metal‐catalyzed C—H activation/annulation was reported. 3‐Phenyl‐2 H ‐benzothiadiazine‐1,1‐dioxide was used as the reaction substrate, and vinylene carbonate and 4‐diazopyrazolone were used as the coupling reagents, respectively. This strategy provides straightforward access to complex N ‐heterocycles in a highly efficient and simple manner.
Topics & Concepts
BenzothiadiazineChemistryAnnulationReagentCombinatorial chemistryCatalysisTransition metalIsoquinolineSubstrate (aquarium)StereochemistryMedicinal chemistryOrganic chemistryGeologyOceanographyCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions