Synthesis and biological evaluation of novel 4,7-disubstituted coumarins as selective tumor-associated carbonic anhydrase IX and XII inhibitors
K. Muni Chandra, Sridhar Goud Nerella, Mohammed Arifuddin, Mallika Alvala, Ravi Alvala, Andrea Angeli, Claudiu T. Supuran
Topics & Concepts
ChemistryCarbonic anhydraseCoumarinGene isoformStereochemistryEnzymeCarbonic anhydrase IIIsozymeGrowth inhibitionBiochemistryIn vitroOrganic chemistryGeneEnzyme function and inhibitionChemical Reactions and MechanismsSynthesis and Catalytic Reactions