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Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Jérôme Mertens, Joseph R. Herdy, Larissa Traxler, Simon T. Schafer, Johannes C. M. Schlachetzki, Lena Böhnke, Dylan A. Reid, Hyungjun Lee, Dina Zangwill, Diana Pereira Fernandes, Ravi Kant Agrawal, Raffaella Lucciola, Lucia Zhou-Yang, Lukas Karbacher, Frank Edenhofer, Shani Stern, Steve Horvath, Apuã C.M. Paquola, Christopher K. Glass, Shauna H. Yuan, Manching Ku, Attila Szücs, Lawrence S.B. Goldstein, Douglas Galasko, Fred H. Gage

2021Cell stem cell245 citationsDOIOpen Access PDF

Topics & Concepts

BiologyTranscriptomeEpigeneticsNeuroscienceDownregulation and upregulationProgenitor cellStem cellCell biologyGene expressionGeneGeneticsEpigenetics and DNA MethylationNeurogenesis and neuroplasticity mechanismsAlzheimer's disease research and treatments
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients | Litcius