Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients
Jérôme Mertens, Joseph R. Herdy, Larissa Traxler, Simon T. Schafer, Johannes C. M. Schlachetzki, Lena Böhnke, Dylan A. Reid, Hyungjun Lee, Dina Zangwill, Diana Pereira Fernandes, Ravi Kant Agrawal, Raffaella Lucciola, Lucia Zhou-Yang, Lukas Karbacher, Frank Edenhofer, Shani Stern, Steve Horvath, Apuã C.M. Paquola, Christopher K. Glass, Shauna H. Yuan, Manching Ku, Attila Szücs, Lawrence S.B. Goldstein, Douglas Galasko, Fred H. Gage
Topics & Concepts
BiologyTranscriptomeEpigeneticsNeuroscienceDownregulation and upregulationProgenitor cellStem cellCell biologyGene expressionGeneGeneticsEpigenetics and DNA MethylationNeurogenesis and neuroplasticity mechanismsAlzheimer's disease research and treatments