Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation
Jia Sun, Fan‐He Song, Jiayi Wu, Long-Qing Zhang, Danyang Li, Shao‐Jie Gao, Dai-Qiang Liu, Ya‐Qun Zhou, Wei Mei
Topics & Concepts
Mitochondrial biogenesisAMPKNeuroinflammationMicrogliaProtein kinase AInflammationEndocrinologyAMP-activated protein kinaseMedicineChemistryInternal medicineMitochondrionKinaseBiochemistryPI3K/AKT/mTOR signaling in cancerPain Mechanisms and TreatmentsOsteoarthritis Treatment and Mechanisms