Maternal Lead Exposure Impairs Offspring Learning and Memory via Decreased GLUT4 Membrane Translocation
Zaihua Zhao, Kejun Du, Tao Wang, Ji-Ye Wang, Zipeng Cao, Xiao-Ming Chen, Han Sol Song, Gang Zheng, Xuefeng Shen
Abstract
GLUT4 over-expression increased the membrane translocation of GLUT4 and glucose uptake, and reversed the Pb-induced impairment to synaptic plasticity and cognition. These findings indicate that Pb exposure impairs synaptic plasticity by reducing the level of GLUT4 in the cell membrane as well as glucose uptake via the PI3K-Akt signaling pathway, demonstrating a novel mechanism for Pb exposure-induced neurotoxicity.
Topics & Concepts
GLUT4Chromosomal translocationOffspringLead exposureLead (geology)Cell biologyBiologyChemistryPregnancyMedicineGeneticsGeneInternal medicinePaleontologyCATSHeavy Metal Exposure and ToxicityTrace Elements in HealthBirth, Development, and Health