A ruthenium–oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy
Luke K. McKenzie, Marie Flamme, Patrick Felder, Johannes Karges, Frédéric Bonhomme, Albert Gandioso, Christian Malosse, Gilles Gasser, Marcel Hollenstein
Abstract
Ruthenium complexes have emerged as a promising class of compounds for use as photosensitizers in photodynamic therapy. Direct conjugation to aptamers enhances their therapeutic usefulness by conveying specificity to Ru-mediated PDT.
Topics & Concepts
AptamerPhotodynamic therapyOligonucleotideNucleolinChemistryRutheniumPhotosensitizerDNACombinatorial chemistryBiophysicsCancer researchMolecular biologyBiochemistryBiologyPhotochemistryCytoplasmOrganic chemistryCatalysisNucleolusAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA Interference and Gene Delivery