Mutagenesis of the cleavage site of (pro)renin receptor abrogates aldosterone-salt-induced hypertension and renal injury in mice
Ziwei Fu, Huaqing Zheng, Kannaree Kaewsaro, Jacob Lambert, Yanting Chen, Tianxin Yang
Abstract
We used a novel mouse model with mutagenesis of the cleavage site of PRR to support soluble PRR as an essential mediator of aldosterone-salt-induced hypertension and also as a potential therapeutic target for patients with mineralocorticoid excess. We firstly report that soluble PRR-dependent pathway medicates the Na + -retaining action of aldosterone in the distal nephron, which opens up a new area for a better understanding of the molecular basis of renal handling of Na + balance and blood pressure.
Topics & Concepts
AldosteroneMineralocorticoid receptorRenin–angiotensin systemReceptorMineralocorticoidEndocrinologyChemistryInternal medicineMediatorNephronCleavage (geology)MutagenesisBlood pressureKidneyPharmacologyMedicineBiologyBiochemistryMutationFracture (geology)GenePaleontologyHormonal Regulation and HypertensionRenin-Angiotensin System StudiesCardiovascular, Neuropeptides, and Oxidative Stress Research