VLM catecholaminergic neurons control tumor growth by regulating CD8 <sup>+</sup> T cells
Ze Zhang, Yehua Li, Xueyuan Lv, Linlin Zhao, Xiaodong Wang
Abstract
Significance We have discovered that the ventrolateral medulla (VLM) catecholaminergic (CA) neurons, a group of neurons that control mouse stress response, are activated in tumor-bearing mice, and the neuronal activity promotes tumor growth in multiple syngeneic and spontaneous mouse tumor models. The tumor-promoting effect of these VLM CA neurons is mediated by cytotoxic T cells. These findings establish an interaction between a tumor and a group of neurons in the mouse brain that influences tumorigenesis and tumor growth by modulating adaptive immunity.
Topics & Concepts
Catecholaminergic cell groupsBiologyCatecholaminergicCentral nervous systemCD8Nervous systemNeuronCancer researchImmune systemInternal medicineEndocrinologyNeuroscienceDopamineImmunologyMedicineCancer, Stress, Anesthesia, and Immune ResponseBrain Metastases and TreatmentReceptor Mechanisms and Signaling