Human amnion-derived mesenchymal stem cells promote osteogenic differentiation of human bone marrow mesenchymal stem cells via H19/miR-675/APC axis
Xiaojie Ma, Yifeng Bian, Hua Yuan, Ning Chen, Yongchu Pan, Weina Zhou, Shiyu Gao, Xin Du, Shushu Hao, Zixin Yan, Xuan Li, Keyue Liu, Fan Xu, Yuli Wang, Yifei Du
Abstract
; whereas its knockdown reversed these effects. Mechanistically, H19 promoted miR-675 expression and contributed to the competitively bounding of miR-675 and Adenomatous polyposis coli (APC), thus significantly activating the Wnt/β-catenin pathway. The results suggested that HAMSCs promote osteogenic differentiation of HBMSCs via H19/miR-675/APC pathway, and supply a potential target for the therapeutic treatment of bone-destructive diseases.
Topics & Concepts
Mesenchymal stem cellCell biologyStem cellWnt signaling pathwayCancer researchChemistryBone marrowBiologyImmunologySignal transductionCancer-related molecular mechanisms researchMicroRNA in disease regulationMesenchymal stem cell research