Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis
Ariel Bensimon, Mattia D. Pizzagalli, Felix Kartnig, Vojtech Dvorak, Patrick Essletzbichler, Georg E. Winter, Giulio Superti‐Furga
Topics & Concepts
Transmembrane proteinProteolysisSubcellular localizationTransmembrane domainCell biologyTransporterProtein degradationBiologyMembrane proteinHEK 293 cellsTransport proteinComputational biologyChemistryBiochemistryGeneEnzymeReceptorMembraneCytoplasmProtein Degradation and InhibitorsCancer-related gene regulationHIV/AIDS drug development and treatment