Dihydropyrimidinones: efficient one-pot green synthesis using Montmorillonite-KSF and evaluation of their cytotoxic activity
Saleem Farooq, Fahad A. Alharthi, Ali Alsalme, Aashiq Hussain, Bashir Ahmad Dar, Abid Hamid, Supriya Koul
Abstract
of 7.1 ± 0.8, 13.1 ± 1.4, 13.8 ± 0.9 and 14.7 ± 1.1 μM against lung (A549), leukemia (THP-1), prostate (PC-3) and colon (Colo-205) cancer lines, respectively. The 16a analog was further checked for its effect on cancer cell properties through clonogenic (colony formation) and scratch motility (wound healing) assays and thereby was found that it reduced both the colony formation and migratory properties of the lung cancer cell line (A549). Further, molecular docking studies were performed with 16a to show its binding mode.
Topics & Concepts
Clonogenic assayCytotoxicityChemistryMTT assayIC50A549 cellCombinatorial chemistryCancer researchStereochemistryBiochemistryCell growthIn vitroBiologyMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of Tetrazole Derivatives