Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance

Donjeta Gjuka, Elio Adib, Kendra Garrison, Jianfeng Chen, Yuxue Zhang, Wenjiao Li, Daniel R. Boutz, Candice Lamb, Yuri Tanno, Amin H. Nassar, Talal El Zarif, Neil Kale, Mehrdad Rakaee, Tarek H. Mouhieddine, Sarah Abou Alaiwi, Alexander Gusev, Thomas E. Rogers, Jianjun Gao, George Georgiou, David J. Kwiatkowski, Everett Stone