A cheap metal catalyzed ring expansion/cross-coupling cascade: a new route to functionalized medium-sized and macrolactones
Shuai Liu, Pengchen Ma, Lu Zhang, Shenyu Shen, Hong-Jie Miao, Le Liu, K. N. Houk, Xin‐Hua Duan, Li‐Na Guo
Abstract
, SCN, and X groups installed concurrently. Density functional theory (DFT) calculations revealed that reductive elimination of the cycloalkyl-Cu(iii) species is a more favorable reaction pathway for the cross-coupling step. Based on the results of experiments and DFT, a Cu(i)/Cu(ii)/Cu(iii) catalytic cycle is proposed for this tandem reaction.
Topics & Concepts
CascadeCyanationCatalysisRing (chemistry)MetalCoupling (piping)Catalytic cycleCombinatorial chemistryChemistryMaterials scienceCrystallographyOrganic chemistryMetallurgyChromatographyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions