A Triple-Regulated Oncolytic Adenovirus Carrying MicroRNA-143 Exhibits Potent Antitumor Efficacy in Colorectal Cancer
Qifeng Luo, Hongming Song, Xiaochong Deng, Jiayi Li, Wei Jian, Junyong Zhao, Xueyu Zheng, Shiva Basnet, Haiyan Ge, Twingle Daniel, Bin Xu, Lin Fang
Abstract
. In a HCT116 xenograft model, intratumoral injection of Ad-RGD-Survivin-ZD55-miR-143 resulted in reduced tumor growth. Furthermore, Ad-RGD-Survivin-ZD55-miR-143 induced apoptosis and decreased the expression level of KRAS in HCT116 xenograft cells. Our results suggested that Ad-RGD-Survivin-ZD55-miR-143 produced a strong antitumor effect by targeting KRAS and that this strategy could broaden the therapeutic options for treating colorectal cancer.
Topics & Concepts
Oncolytic virusColorectal cancermicroRNACancer researchOncolytic adenovirusMedicineCancerBiologyInternal medicineGeneTumor cellsGeneticsVirus-based gene therapy researchCancer Research and TreatmentsRNA Interference and Gene Delivery