Electrochemical-induced benzyl C–H amination towards the synthesis of isoindolinones <i>via</i> aroyloxy radical-mediated C–H activation
Mingming Yu, Yuhan Gao, Lin Zhang, Yingjie Zhang, Yiyan Zhang, Hong Yi, Zhiliang Huang, Aiwen Lei
Abstract
A novel electrochemical strategy for the synthesis of valuable isoindolinones has been developed with the use of simple o -alkylbenzoic acid and alkyl nitrile as starting materials under metal-catalyst and external oxidant-free conditions.
Topics & Concepts
AminationChemistryElectrochemistryRadicalCombinatorial chemistryMedicinal chemistryCatalysisOrganic chemistryElectrodePhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsOxidative Organic Chemistry Reactions