Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones
Deguang Liang, Yan Feng, Fereshteh Zandkarimi, Hua Wang, Zeda Zhang, Jinnie Kim, Yanyan Cai, Wei Gu, Brent R. Stockwell, Xuejun Jiang
Topics & Concepts
GPX4Phospholipid-hydroperoxide glutathione peroxidaseBiologyDownregulation and upregulationHormone receptorPhospholipidReceptorCell biologyAndrogen receptorHormoneProgrammed cell deathAntioxidantLipid peroxidationEstrogen receptorCancer researchGlutathioneGlutathione peroxidaseProstate cancerEnzymeBiochemistryCancerApoptosisGeneGeneticsBreast cancerMembraneFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer