Remote ischemic conditioning in Ossabaw minipigs induces the release of humoral cardioprotective triggers, but the myocardium does not respond with reduced infarct size
Helmut Raphael Lieder, Andreas Skyschally, Michael Sturek, Gerd Heusch, Petra Kleinbongard
Abstract
Ischemic conditioning reduces myocardial infarct size in all species tested so far. In the present study, we used Ossabaw minipigs that had a genetic predisposition to, but not yet established a metabolic syndrome. In these pigs, remote ischemic conditioning (RIC) induced the release of cardioprotective triggers but did not reduce infarct size. Transfer of their plasma, however, reduced infarct size in isolated recipient rat hearts, along with signal transducer and activator of transcription (STAT)3 activation.
Topics & Concepts
MedicineIschemiaSTAT3CardiologyInternal medicineIschemic preconditioningInfarctionSTAT proteinMyocardial infarctionCoronary occlusionChemistrySignal transductionBiochemistryCardiac Ischemia and ReperfusionAnesthesia and Neurotoxicity ResearchNeuroscience and Neuropharmacology Research