Litcius/Paper detail

Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts

Huixun Du, Jacob Rose, Joanna Bons, Guo Li, Taylor R. Valentino, Fei Wu, Jordan B. Burton, Nathan Basisty, Max Manwaring-Mueller, Priya Makhijani, Nan Chen, Veronica Chang, Shawn Winer, Judith Campisi, David Furman, András Nagy, Birgit Schilling, Daniel A. Winer

2025GeroScience11 citationsDOIOpen Access PDF

Topics & Concepts

SenescencePhenotypeTranscriptomeCell biologyPulmonary fibrosisBiologyCellMechanotransductionIdiopathic pulmonary fibrosisFibrosisGene expressionLungGenePathologyGeneticsMedicineInternal medicineTelomeres, Telomerase, and SenescenceNeutrophil, Myeloperoxidase and Oxidative MechanismsCellular Mechanics and Interactions