Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts
Huixun Du, Jacob Rose, Joanna Bons, Guo Li, Taylor R. Valentino, Fei Wu, Jordan B. Burton, Nathan Basisty, Max Manwaring-Mueller, Priya Makhijani, Nan Chen, Veronica Chang, Shawn Winer, Judith Campisi, David Furman, András Nagy, Birgit Schilling, Daniel A. Winer
Topics & Concepts
SenescencePhenotypeTranscriptomeCell biologyPulmonary fibrosisBiologyCellMechanotransductionIdiopathic pulmonary fibrosisFibrosisGene expressionLungGenePathologyGeneticsMedicineInternal medicineTelomeres, Telomerase, and SenescenceNeutrophil, Myeloperoxidase and Oxidative MechanismsCellular Mechanics and Interactions