High-intensity exercise impairs extradiaphragmatic respiratory muscle perfusion in patients with COPD
Zafeiris Louvaris, Antenor Rodrigues, Sauwaluk Dacha, Tin Gojević, Wim Janssens, Ioannis Vogiatzis, Rik Gosselink, Daniël Langer
Abstract
We simultaneously assessed the blood flow index (BFI) in three respiratory muscles during hyperpnea and high-intensity constant-load cycling sustained at comparable levels of work of breathing and respiratory neural drive in patients with COPD. We demonstrated that high-intensity exercise impairs respiratory muscle perfusion, as intercostal, scalene, and abdominal BFI increased during hyperpnea but not during cycling. Insufficient adjustment in respiratory muscle perfusion during exercise was associated with greater dyspnea sensations in patients with COPD.
Topics & Concepts
HyperpneaMedicineCOPDRespiratory systemPerfusionWork of breathingCardiologyIntensity (physics)Physical exerciseAnesthesiaInternal medicinePhysicsQuantum mechanicsChronic Obstructive Pulmonary Disease (COPD) ResearchCardiovascular and exercise physiologyHeart Rate Variability and Autonomic Control