The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations
Zhenqiang Xia, Ridong Huang, Xinglong Zhou, Yingying Chai, Hai Chen, Lingling Ma, Quanwei Yu, Ying Li, Weimin Li, Yang He
Topics & Concepts
PharmacophoreChemistryPyrimidineEGFR inhibitorsTyrosine kinaseIC50KinaseMutantStructure–activity relationshipStereochemistryBiochemistryEpidermal growth factor receptorIn vitroSignal transductionReceptorGeneLung Cancer Treatments and MutationsCancer therapeutics and mechanismsHER2/EGFR in Cancer Research