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Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes

Yueyi Chen, Amol D. Sonawane, Manda Rajesh, Ranjith Kumar Gadi, J.J.G. Tesmer, Arun K. Ghosh

2023European Journal of Medicinal Chemistry12 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryKinaseActive siteBinding siteDrug developmentLigand (biochemistry)Drug discoveryBiochemistryStereochemistryG protein-coupled receptor kinasePharmacologyEnzymeG protein-coupled receptorReceptorDrugBiologyReceptor Mechanisms and SignalingProtein Kinase Regulation and GTPase SignalingChemical Synthesis and Analysis
Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes | Litcius