A general nickel-catalyzed highly regioselective hydroarylation of unactivated alkenes enabled by the picolinamide auxiliary
Lanlan Zhang, Chun Luo, Haoran Shi, Lin Zhu, Yuanqing Xu, Zhong‐Yan Cao, Chao Wang
Abstract
A practical method for regioselective hydroarylation of unactivated γ- or δ-vinyl alkylamines has been reported, enabling facile preparation of highly value-added ε- or ζ-aryl alkylamines. The protocol employs nickel catalysis, shows high functional group tolerance and can be used for modifying bio-related molecules.
Topics & Concepts
RegioselectivityCatalysisNickelArylCombinatorial chemistryChemistryFunctional groupMoleculeStereoisomerismOrganic chemistryAlkylPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis