Clinical impact of obesity on oscillometry lung mechanics in adults with asthma
Rory Chan, Brian J. Lipworth
Abstract
BackgroundIn the year 2035, projections have estimated that 5% of the Scottish population will be morbidly obese defined as a body mass index (BMI) greater than or equal to 40 kg/m2. Airway oscillometry is an effort-independent test akin to bronchial sonar which measures resistance and compliance.ObjectiveTo evaluate the impact of obesity on lung mechanics using oscillometry.MethodsClinical data for 188 patients with respiratory physician–diagnosed moderate-to-severe asthma were retrospectively collected and analyzed.ResultsObesity (BMI 30-39.9 kg/m2) and morbid obesity (BMI ≥ 40 kg/m2) were associated with a significantly worse heterogeneity of peripheral resistance between 5 Hz and 20 Hz and peripheral compliance as low-frequency reactance at 5 Hz and area under the reactance curve, as compared with normal weight (BMI 18.5-24.9 kg/m2). Cluster analysis incorporating oscillometry identified a patient cohort who was older, obese, and female with combined impairment of spirometry and oscillometry coupled with more frequent severe exacerbations.ConclusionObesity is associated with worse peripheral airway dysfunction in moderate-to-severe asthma, including a patient cluster who was older, obese, and female with more frequent exacerbations.