Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib
Cheryl A.C. Peretz, Lisa H.F. McGary, Tanya Kumar, Hunter Jackson, Jose Jacob, Robert Durruthy-Durruthy, Mark J. Levis, Alexander E. Perl, Benjamin J. Huang, Catherine C. Smith
Abstract
Key Points Single-cell sequencing exposes previously unmeasurable complexity of tumor heterogeneity and clonal evolution on quizartinib. Single-cell sequencing reveals on- and off-target mechanisms of resistance to quizartinib, which can preexist therapy.
Topics & Concepts
DNACellDNA sequencingComputational biologySingle-cell analysisSingle cell sequencingBiologyGeneticsMutationGeneExome sequencingCancer Genomics and DiagnosticsPancreatic and Hepatic Oncology ResearchLung Cancer Treatments and Mutations