Store-operated Ca<sup>2+</sup> entry inhibition ameliorates high glucose and ANG II-induced podocyte apoptosis and mitochondrial damage
Yu Tao, Parisa Yazdizadeh Shotorbani, Denise M. Inman, Paromita Das‐Earl, Rong Ma
Abstract
This study tested the hypothesis that overwhelming store-operated Ca 2+ entry is a novel mechanism contributing to high glucose- and angiotensin II-induced podocyte apoptosis and mitochondrial injury.
Topics & Concepts
PodocyteApoptosisCell biologyChemistryMitochondrionBiologyEndocrinologyBiochemistryKidneyProteinuriaPancreatic function and diabetesMitochondrial Function and PathologyIon Transport and Channel Regulation