The KEAP1-Cullin3-RBX1-Nrf2 Axis in Redox Homeostasis: Molecular Mechanisms, Pathophysiological Roles, and Precision Therapeutic Opportunities
Mayank Attri, Omkar Kumar Kuwar
Topics & Concepts
KEAP1RegulatorCell biologyOxidative stressUbiquitin ligaseChemistryEndoplasmic-reticulum-associated protein degradationMechanism (biology)Transcription factorUbiquitinOxidative phosphorylationSignal transductionRegulation of gene expressionAntioxidantImmune systemMetabolic pathwayCytoprotectionBiologyBiochemistryCysteineComputational biologyEndogenyIntracellularNF-κBGene expressionTranscriptional regulationHomeostasisAutophagosomeGeneGenomics, phytochemicals, and oxidative stressEndoplasmic Reticulum Stress and DiseaseRedox biology and oxidative stress