A Synergistic DNA-polydopamine-MnO<sub>2</sub> Nanocomplex for Near-Infrared-Light-Powered DNAzyme-Mediated Gene Therapy
Huaixin Zhao, Zhili Zhang, Duo Zuo, Linghui Li, Feng Li, Dayong Yang
Abstract
experiments show that the PM-induced temperature elevation enhances the Egr-1 mRNA cleavage activity of DNAzyme, promoting downregulation of the Egr-1 protein in tumor cells. In addition, the temperature elevation induces heat stress, achieving a synergistic tumor ablation effect.
Topics & Concepts
DeoxyribozymeChemistryPhotothermal therapyDNAIn vivoBiophysicsNanotechnologyBiochemistryMaterials scienceBiologyBiotechnologyAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics