Human Parainfluenza Virus Type 2 V Protein Modulates Iron Homeostasis
Keisuke Ohta, Naoki Saka, Machiko Nishio
Abstract
hPIV-2 V protein interferes with interaction between FTH1 and NCOA4 and inhibits NCOA4-mediated ferritin degradation, leading to the inhibition of iron release to the cytoplasm. This iron homeostasis modulation allows infected cells to avoid apoptotic cell death, resulting in effective growth of hPIV-2.
Topics & Concepts
BiologyCytoplasmFerritinCell biologyHomeostasisIron homeostasisProgrammed cell deathTransport proteinApoptosisVirologyBiochemistryMetabolismViral Infections and VectorsMosquito-borne diseases and controlVirology and Viral Diseases