Involvement of sarco/endoplasmic reticulum Ca<sup>2<b>+</b></sup>-ATPase (SERCA) in mPRα (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation
Yefei Pang, Peter Thomas
Abstract
The rapid effects of progesterone on cytosolic Ca 2+ levels and relaxation of VSMCs through mPRα involve regulation of the functions of SERCA2 and PLB through Gi, MAP kinase, and Akt signaling pathways and downregulation of RhoA activity.
Topics & Concepts
Endoplasmic reticulumSERCADownregulation and upregulationChemistryCytosolCell biologyVascular smooth muscleRHOAKinaseATPaseProtein kinase BSignal transductionEndocrinologyInternal medicineEnzymeSmooth muscleBiologyBiochemistryMedicineGeneProtein Kinase Regulation and GTPase SignalingMagnesium in Health and DiseaseIon Transport and Channel Regulation