A functional polysaccharide from <i>Eriobotrya japonica</i> relieves myocardial ischemia injury <i>via</i> anti-oxidative and anti-inflammatory effects
Xiaoli Huang, Ranran Hou, Wei Pan, Ding‐Tao Wu, Wenwen Zhao, Qiu Li
Abstract
. Interestingly, in the murine model of MIRI, administration of EJP effectively improved post-I/R heart contraction and limited the infarct size. Moreover, EJP significantly attenuated IR-induced oxidative damage and inflammatory reaction, as evidenced by decreasing MDA, IL-6, and TNF-α contents and increasing SOD activity and GSH-Px expression. In addition, we proved that EJP not only had no nephrotoxicity but also demonstrated a protective effect on the kidneys through HE staining and biochemical analysis. In sum, EJP, with a significant protective effect against myocardial I/R injury by showing anti-inflammatory and anti-oxidative activities, may become a meaningful drug candidate for the treatment of myocardial I/R injury.