Short-term starvation inhibits CD36 N-glycosylation and downregulates USP7 UFMylation to alleviate RBPJ-maintained T cell exhaustion in liver cancer
Banglun Pan, Siyan Chen, Hao Wu, Xiaoxia Zhang, Zhu Zhang, Dongjie Ye, Yuxin Yao, Yue Luo, Xinyu Zhang, Xiaoqian Wang, Nanhong Tang
Abstract
These findings uncovered a novel mechanism by which N-glycosylation participated in UFMylation/ubiquitination to regulate T cell exhaustion, and we underscored the potential of targeting USP7 and RBPJ in anti-tumor immunotherapy strategies.
Topics & Concepts
StarvationCD36CancerDownregulation and upregulationGlycosylationCancer researchChemistrySuppressorTerm (time)Liver cancerCell biologyBiologyMedicineInternal medicineEndocrinologyGeneBiochemistryQuantum mechanicsPhysicsUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors ResearchCancer, Hypoxia, and Metabolism