LncRNA MEG3 regulates microglial polarization through KLF4 to affect cerebral ischemia-reperfusion injury
Tianhao Li, Yuru Luo, Peng Zhang, Shewei Guo, Hongwei Sun, Dongming Yan, Xianzhi Liu, Bo Yang
Abstract
To study the role of long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) in cerebral ischemia-reperfusion (I/R) injury, we clarified the mechanism by which lncRNA MEG3 regulates the secretion of inflammatory cytokines in microglia through in vitro and in vivo experiments. We discovered that inhibition of MEG3 could alleviate cerebral I/R injury via inhibiting M1 polarization and promoting M2 polarization through Krüppel-like factor 4 (KLF4), indicating an effective theoretical basis for potential therapeutic targets of cerebral I/R injury.
Topics & Concepts
MicrogliaMEG3In vivoKLF4IschemiaSmall interfering RNAReperfusion injuryChemistryInflammationDownregulation and upregulationCell biologyBiologyMolecular biologyTransfectionLong non-coding RNAMedicineInternal medicineImmunologyBiochemistryTranscription factorGeneSOX2BiotechnologyCancer-related molecular mechanisms researchCircular RNAs in diseasesMicroRNA in disease regulation