Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
Omnia E. Hussein, Walaa G. Hozayen, May Bin‐Jumah, Mousa O. Germoush, Sanaa M. Abd El‐Twab, Ayman M. Mahmoud
Topics & Concepts
Oxidative stressPharmacologyReactive oxygen speciesLipid peroxidationChemistryInflammationApoptosisAntioxidantPeroxisome proliferator-activated receptorMethotrexateLiver injuryBiochemistryMedicineInternal medicineReceptorChemotherapy-induced organ toxicity mitigationAcute Lymphoblastic Leukemia researchDrug-Induced Hepatotoxicity and Protection