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Trans-cleavage activity of Cas12a effectors can be unleashed by both double-stranded DNA and single-stranded RNA targeting in absence of PAM

Guohui Xiao, Hongyu Shi, Meixia Liu, Min Huang, Siqi Li, Xuefeng Zhou, Hengfei Li, Guoliang Zhang

2025International Journal of Biological Macromolecules8 citationsDOI

Topics & Concepts

RNADNACleavage (geology)EffectorChemistryDouble strandedCell biologyMolecular biologyBiophysicsBiologyComputational biologyBiochemistryGenePaleontologyFracture (geology)CRISPR and Genetic EngineeringRNA regulation and diseaseRNA Interference and Gene Delivery
Trans-cleavage activity of Cas12a effectors can be unleashed by both double-stranded DNA and single-stranded RNA targeting in absence of PAM | Litcius